2023
Waleed A. Badawi, Mahmoud Rashed, Alessio Nocentini, Alessandro Bonardi, Mohammad M. Abd-Alhaseeb, Sara T. Al-Rashood,Giri Babu Veerakanellore, Taghreed A. Majrashi, Eslam B. Elkaeed,
Bahaa Elgendy, Paola Gratter, Claudiu T. Supuran, Wagdy M. Eldehna, Mohamed Elagawany.
Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights.
Journal of Enzyme Inhibition and Medicinal Chemistry 38 (1), 2201407
Cyrielle Billon, Sadichha Sitaula, Subhashis Banerjee, Ryan Welch,
Bahaa Elgendy, Lamees Hegazy, Tae Gyu Oh, Melissa Kazantzis, Arindam Chatterjee, John Chrivia, Matthew E Hayes, Weiyi Xu, Angelica Hamilton, Janice M Huss, Lilei Zhang, John K Walker, Michael Downes, Ronald M Evans, Thomas P Burris.
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.
ACS Chemical Biology 18 (4), 756-771
Mahmoud A. Ragab, Wagdy M. Eldehna, Alessio Nocentini, Alessandro Bonardi, Hazem E. Okda,
Bahaa Elgendy, Tarek S. Ibrahim, Mohammad M. Abd-Alhaseeb, Paola Gratteri, Claudiu T. Supuran, Ahmed A. Al-Karmalawy, Mohamed Elagawany
4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments.
European Journal of Medicinal Chemistry 250, 115180
2022
Meghan H Murray, Aurore Cecile Valfort, Thomas Koelblen, Céline Ronin, Fabrice Ciesielski, Arindam Chatterjee, Giri Babu Veerakanellore,
Bahaa Elgendy, John K Walker, Lamees Hegazy, Thomas P Burris.
Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB.
Nature Communications 13 (1), 7131
Mohamed Elagawany, Ayman Abo Elmaaty, Ahmed Mostafa, Noura M Abo Shama, Eman Y Santali,
Bahaa Elgendy, Ahmed A Al-Karmalawy.
Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease.
Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), 2112-2132
Kristine Griffett, Matthew Hayes, Gonzalo Bedia-Diaz, Kevin Appourchaux, Ryan Sanders, Michael P Boeckman, Thomas Koelblen, Jinsong Zhang, Ira G Schulman,
Bahaa Elgendy, Thomas P Burris.
Antihyperlipidemic Activity of Gut-Restricted LXR Inverse Agonists.
ACS Chemical Biology 17 (5), 1143-1154
Wesley T Hodges, Chaowapong Jarasvaraparn, Daniel Ferguson, Kristine Griffett, Lauren E Gill, Yana Chen, Ma Xenia G Ilagan, Lamees Hegazy,
Bahaa Elgendy, Kevin Cho, Gary J Patti, Kyle S McCommis, Brian N Finck.
Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice.
Journal of Biological Chemistry 298 (2)
Elizabeth Geerling, Valerie Murphy, E Taylor Stone, Andreu Gazquez Casals, Mariah A Hassert, Austin T O'Dea, Feng Cao, Maureen J Donlin,
Bahaa El-Dien M Elgendy, Mohamed Elagawany, Vasiliki Pardali, Erofili Giannakopoulou, Grigoris Zoidis, Daniel V Schiavone, Alex J Berkowitz, Nana B Agyemang, Ryan P Murelli, John E Tavis, Amelia K Pinto, James DD Brien.
Metal Coordinating Inhibitors of Rift Valley Fever virus Replication.
bioRxiv 2022/1/1
Cyrielle Billon, Subhashis Banerjee, Sadichha Situala, Ryan Welch, Lamees Hegazy,
Bahaa Elgendy, Tae Gyu Oh, Melissa Kazantzis, Arindam Chatterjee, John Chrivia, Matthew Hayes, Weiyi Xu, Angela Hamilton, Jan Huss, Lilei Zhang, John K Walker, Michael Downes, Ronald Evans, Thomas Burris.
A Synthetic ERRα Agonist Induces an Acute Aerobic Exercise Response and Enhances Exercise Capacity
bioRxiv , 2022.10. 05.510974
2021
Bathini Thissera, Irene Hallyburton, Che Julius Ngwa, Hafsa Cherif-Silini, Ahmed SI Hassane, Mark Anderson, Lorna A Campbell, Nicole Mutter, Manal Eshelli, Usama R Abdelmohsen, Mohammed Yaseen, Gabriele Pradel, Lassaad Belbahri,
Bahaa Elgendy, Lamees Hegazy, Mostafa E Rateb.
Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators.
Bioorganic chemistry 115, 105215
2020
Tarek S Ibrahim, Mohamed M Hawwas, Ehab S Taher, Nabil A Alhakamy, Mohamed A Alfaleh, Mohamed Elagawany,
Bahaa Elgendy, Gamal M Zayed, Mamdouh FA Mohamed, Zakaria K Abdel-Samii, Yaseen AMM Elshaier.
Design and synthesis of novel pyrazolo [3, 4-d] pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy.
Bioorg. Chem., 2020,105, 104352
Mohamed Shahien, Mohamed Elagawany, Sadichha Sitaula, Shaimaa S Goher, Sheryl L Burris, Ryan Sanders, Amer Avdagic, Cyrielle Billon, Lamees Hegazy, Thomas P Burris,
Bahaa Elgendy*.
Modulation of estrogen-related receptors subtype selectivity: Conversion of an ERRβ/γ selective agonist to ERRα/β/γ pan agonists. Bioorg. Chem., 2020,102, 104079.
Elzahhar, P. A.; Abd El Wahab, S. M.; Elagawany, M.; Daabees, H.; Belal, A.; EL-Yazbi, A.; Eid, A.; Alaaeddine, R.; Hegazy, R.; Allam, R.; Helmy, M.;
Elgendy, B.; Angeli, A.; El-Hawash, S.; Supuran, C. T.
Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases. Eur. J. Med. Chem. 2020, 200, 112439.
Ibrahim, T. S.; Salem, I. M.; Mostafa, S. M.; El-Sabbagh, O. I.; ElKhamisi, M. K.; Hegazy, L.;
Elgendy, B*. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold. Bioorg. Chem., 2020, 100, 103878.
Saeed, W.; Elagawany, M.; Azab, M. M.; Amin, A. S.; Rath, N. P.; Hegazy, L.;
Elgendy, B*. Catalyst-and organic solvent-free synthesis, structural, and theoretical studies of 1-arylidenamino-2,4-disubstituted-2-imidazoline-5-ones. Results in Chemistry 2020, 2, 100042.
2019
Goher, S.S.; Griffett, K.; Hegazy, L.; Elagawany, M.; Arief, M.M.H.; Avdagic, A.; Banerjee, S.; Burris, T.P.;
Elgendy, B*. Development of novel liver X receptor modulators based on a 1,2,4-triazole scaffold. Bioorg. Med. Chem. Lett., 2019, 29 (3), 449-453.
2018
Cao, F.; Orth, C.; Donlin, M.J.; Adegboyega, P.; Meyers, M.J.; Murelli, R.P.; Elagawany, M.;
Elgendy, B.; Tavis, J.
Synthesis and evaluation of troponoids as a new class of antibiotics. ACS Omega, 2018, 3 (11), 15125-15133.
Elagawany, M.; Hegazy, L.; Cao, F.; Donlin, M.J.; Rath, N.; Tavis, J.;
Elgendy, B*.
Identification of 4-isopropyl–thiotropolone as a novel anti-microbial: regioselective synthesis, NMR characterization, and biological evaluation. RSC Advances, 2018, 8 (52), 29967-29975.
El-Sayed, S.; Ali, M.;
Elgendy, B.; Dandash, S.; Issac, Y.; Saad, R.; Azab, M.; Mohamed, M.
Identification of novel small molecule inhibitors against the NS3/4A protease of hepatitis C virus genotype 4a.
Curr. Pharm. Des., 2018, 24 (37), 4484-4491.
2016
Mabied, A.F.; Girgis, A.S.; Shalaby, E.M.; George, R.F.;
Elgendy, B.; Baseliouse, F.N.
Stereoselective Synthesis, Structural and Spectroscopic Study of 4,5,11-Triazatricyclo[6.2.1.0*2,6*]Undec-5-ene. J. Heterocyclic Chem., 2016, 53, 1074-1080.
2015
Flaveny, C.A.; Griffett, K.;
Elgendy, B.; Kazantzis, M. Sengupta, M.; Amelio, A.L.; Chatterjee, A.; Walker, J.; Solt, L.A.; Kamenecka, T.M.; Burris, T.P.
Broad Anti-Tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis. Cancer Cell, 2015, 28 (1), 42-56.
2014
Shalaby, E.M.; Girgis, A.S.; Moustafa, A.M.; ElShaabiny, A.M.;
Elgendy, B.; Mabied, A.F.; Farag, I.S. A.
Regioselective Synthesis, Stereochemical Structure, Spectroscopic Characterization and Geometry Optimization of Dispiro[3H-Indole-3,2′-Pyrrolidine-3′,3′′-Piperidines].
J. Mol. Struct., 2014, 1075, 327–334.
2013
Khan, P.M.;
Elgendy, B.; Kumar, N.; Chang, M.R.; Lin, L.; Ruiz, C.H.; Cameron, M.D.; Griffin, P.R.; Kamenecka, T.M.
Small Molecule Amides as Potent ROR-γ Selective Modulators.
Bioorg. Med. Chem. Lett., 2013, 23, 532-536.
2012
Draghici, B.;
Elgendy, B.; Katritzky, A.R.
Synthesis of Benzoxazines, Quinazolines and 4H-Benzo[e][1,3]thiazine by ANRORC Rearrangements of 1,2,4-Oxadiazoles.
Synthesis, 2012, 44, 547–550.
Ghazvini Zadeh, E.H.;
Elgendy, B.; Pop, A.G.; Katritzky, A.R.
Synthesis of chiral α-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines.
Med. Chem. Commun., 2012, 3, 52-55.
2011
Hall, A.C.; Griffith, T.N.; Tsikolia, M..; Kotey, F.O.; Gill, N.; Humbert, D.J.; Watt, E.E.; Yermolina, Y.A.; Goel, S.;
Elgendy, B.; Hall, C.D.
Cyclohexanol Analogues are Positive Modulators of GABAA Receptor Currents and Act as General Anaesthetics in Vivo.
Eur. J. Pharmacol. 2011, 667, 175–181.
2010
Katritzky, A.R.;
Elgendy, B.; Draghici, B.; Fedoseyenko, D.; Fadli, A.; Metais, E.
1H, 13C, and 15N NMR Spectra of Some Pyridazine Derivatives. Magn. Reson. Chem. 2010, 48(5), 397-402.
2009
2008
2007