Selected Publications
2020
Tarek S Ibrahim, Mohamed M Hawwas, Ehab S Taher, Nabil A Alhakamy, Mohamed A Alfaleh, Mohamed Elagawany, Bahaa Elgendy, Gamal M Zayed, Mamdouh FA Mohamed, Zakaria K Abdel-Samii, Yaseen AMM Elshaier. Design and synthesis of novel pyrazolo [3, 4-d] pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy. Bioorg. Chem., 2020,105, 104352
Kristine Griffett, Gonzalo Bedia-Diaz, Bahaa Elgendy, Thomas P Burris. REV-ERB agonism improves liver pathology in a mouse model of NASH. PLoS ONE 2020, 15(10): e0236000. https://doi.org/10.1371/journal.pone.0236000.
Wessam S Abdrabo, Bahaa Elgendy,* Kamal A Soliman, Hany M Abd El-Lateef, Ahmed H Tantawy. Synthesis, assessment and corrosion protection investigations of some novel peptidomimetic cationic surfactants: Empirical and theoretical insights. J. Mol. Liq. 2020, 315, 113672.
Mohamed Shahien, Mohamed Elagawany, Sadichha Sitaula, Shaimaa S Goher, Sheryl L Burris, Ryan Sanders, Amer Avdagic, Cyrielle Billon, Lamees Hegazy, Thomas P Burris, Bahaa Elgendy*. Modulation of estrogen-related receptors subtype selectivity: Conversion of an ERRβ/γ selective agonist to ERRα/β/γ pan agonists. Bioorg. Chem., 2020,102, 104079.
Elzahhar, P. A.; Abd El Wahab, S. M.; Elagawany, M.; Daabees, H.; Belal, A.; EL-Yazbi, A.; Eid, A.; Alaaeddine, R.; Hegazy, R.; Allam, R.; Helmy, M.; Elgendy, B.; Angeli, A.; El-Hawash, S.; Supuran, C. T. Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases. Eur. J. Med. Chem. 2020, 200, 112439.
Cao, F.; Tavis, J. E.; Donlin, M. J.; Meyers, M. J.; Murelli, R. P.; Cari, O.; Elgendy, B. Inhibitors of nucleotidyltransferase superfamily enzymes as antibiotics. US Patent App. 16/614,335.
Ibrahim, T. S.; Salem, I. M.; Mostafa, S. M.; El-Sabbagh, O. I.; ElKhamisi, M. K.; Hegazy, L.; Elgendy, B*. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold. Bioorg. Chem., 2020, 100, 103878.
Saeed, W.; Elagawany, M.; Azab, M. M.; Amin, A. S.; Rath, N. P.; Hegazy, L.; Elgendy, B*. Catalyst-and organic solvent-free synthesis, structural, and theoretical studies of 1-arylidenamino-2,4-disubstituted-2-imidazoline-5-ones. Results in Chemistry 2020, 2, 100042.
2019
Elagawany, M.; Hegazy, L.; Elgendy, B*. Catalyst- and Organic Solvent-Free Synthesis of Thioacids in Water. Tetrahedron Lett. 2019, 60, 2018-2021.
Elagawany, M.; Farid, N.F.; Elgendy, B.; Abdelmomen, E.H.; Abdelwahab, N.S. Baclofen Impurities: Facile Synthesis and Novel Environmentally Benign Chromatographic Method for their Simultaneous Determination in Baclofen. Biomed. Chromatogr. 2019, e4579.
Goher, S.S.; Griffett, K.; Hegazy, L.; Elagawany, M.; Arief, M.M.H.; Avdagic, A.; Banerjee, S.; Burris, T.P.; Elgendy, B*. Development of novel liver X receptor modulators based on a 1,2,4-triazole scaffold. Bioorg. Med. Chem. Lett., 2019, 29 (3), 449-453.
2018
Elgendy, B.*; Goher, S.S.; Hegazy, L.; Arief, M. M. H.; Burris, T.P. Recent Advances in the Medicinal Chemistry of Liver X Receptors. J. Med. Chem., 2018, 61 (24), 10935-10956.
Cao, F.; Orth, C.; Donlin, M.J.; Adegboyega, P.; Meyers, M.J.; Murelli, R.P.; Elagawany, M.; Elgendy, B.; Tavis, J. Synthesis and evaluation of troponoids as a new class of antibiotics. ACS Omega, 2018, 3 (11), 15125-15133.
Elagawany, M.; Hegazy, L.; Cao, F.; Donlin, M.J.; Rath, N.; Tavis, J.; Elgendy, B*. Identification of 4-isopropyl–thiotropolone as a novel anti-microbial: regioselective synthesis, NMR characterization, and biological evaluation. RSC Advances, 2018, 8 (52), 29967-29975.
El-Sayed, S.; Ali, M.; Elgendy, B.; Dandash, S.; Issac, Y.; Saad, R.; Azab, M.; Mohamed, M. Identification of novel small molecule inhibitors against the NS3/4A protease of hepatitis C virus genotype 4a. Curr. Pharm. Des., 2018, 24 (37), 4484-4491.
2016
Eno, M.; Elgendy, B.; Cameron, M. P450 3A Catalyzed O-dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2. Chem. Res. Toxicol. 2016, 29, 784−796.
Mabied, A.F.; Girgis, A.S.; Shalaby, E.M.; George, R.F.; Elgendy, B.; Baseliouse, F.N. Stereoselective Synthesis, Structural and Spectroscopic Study of 4,5,11-Triazatricyclo[6.2.1.0*2,6*]Undec-5-ene. J. Heterocyclic Chem., 2016, 53, 1074-1080.
2015
Abd El-Lateef, H.M.; Abu-Dief, A.M.; Elgendy, B. Investigation of adsorption and inhibition effects of some novel anil compounds towards mild steel in H2SO4 solution: Electrochemical and theoretical quantum studies. J. Electroanal. Chem. 2015, 758, 135-147.
Flaveny, C.A.; Griffett, K.; Elgendy, B.; Kazantzis, M. Sengupta, M.; Amelio, A.L.; Chatterjee, A.; Walker, J.; Solt, L.A.; Kamenecka, T.M.; Burris, T.P. Broad Anti-Tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis. Cancer Cell, 2015, 28 (1), 42-56.
El-Gendy, B.; Rateb, M.E. Antibacterial Activity of Diketopiperazines Isolated from a Marine Fungus using t-Butoxycarbonyl Group as a Simple Tool for Purification. Bioorg. Med. Chem. Lett., 2015, 25 (16), 3125-3128.
2014
Banerjee S.; Wang, Y.; Solt, L.A.; Griffett, K.; Kazantzis, M.; Amador A.; Elgendy, B.; Huitron-Resendiz, S.; Roberts A.J.; Shin, Y.; Kamenecka T.M.; Burris, T.P. Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behavior. Nat. Commun. 2014, Dec 23; 5:5759. doi: 10.1038/ncomms6759.
Belal, A.; Elgendy, B*. Pyrrolizines: Promising Scaffolds for Anticancer Drugs. Bioorg. Med. Chem., 2014, 22, 46–53.
Shalaby, E.M.; Girgis, A.S.; Moustafa, A.M.; ElShaabiny, A.M.; Elgendy, B.; Mabied, A.F.; Farag, I.S. A. Regioselective Synthesis, Stereochemical Structure, Spectroscopic Characterization and Geometry Optimization of Dispiro[3H-Indole-3,2′-Pyrrolidine-3′,3′′-Piperidines]. J. Mol. Struct., 2014, 1075, 327–334.
2013
Elgendy, B.; Ghazvini Zadeh, E.H.; Sotuyo, A.C.; Pillai, G.G.; Katritzky, A.R. α-Substitution Effects on the Ease of S → N-Acyl Transfer in Aminothioesters. Chem. Biol. Drug Des., 2013, 81 (5), 577–582.
Griffett, K.; Solt, L.A.; Elgendy, B.; Kamenecka, T.M.; Burris, T.P. A Liver Selective LXR Inverse Agonist that Suppresses Hepatic Steatosis. ACS Chem. Biol., 2013, 8 (3), 559–567.
Khan, P.M.; Elgendy, B.; Kumar, N.; Chang, M.R.; Lin, L.; Ruiz, C.H.; Cameron, M.D.; Griffin, P.R.; Kamenecka, T.M. Small Molecule Amides as Potent ROR-γ Selective Modulators. Bioorg. Med. Chem. Lett., 2013, 23, 532-536.
2012
Draghici, B.; Elgendy, B.; Katritzky, A.R. Synthesis of Benzoxazines, Quinazolines and 4H-Benzo[e][1,3]thiazine by ANRORC Rearrangements of 1,2,4-Oxadiazoles. Synthesis, 2012, 44, 547–550.
Ghazvini Zadeh, E.H.; Elgendy, B.; Pop, A.G.; Katritzky, A.R. Synthesis of chiral α-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines. Med. Chem. Commun., 2012, 3, 52-55.
2011
Hall, A.C.; Griffith, T.N.; Tsikolia, M..; Kotey, F.O.; Gill, N.; Humbert, D.J.; Watt, E.E.; Yermolina, Y.A.; Goel, S.; Elgendy, B.; Hall, C.D. Cyclohexanol Analogues are Positive Modulators of GABAA Receptor Currents and Act as General Anaesthetics in Vivo. Eur. J. Pharmacol. 2011, 667, 175–181.
Draghici, B.; Hansen F.K.; Buciumas, A.; Elgendy, B.; Todadze, E.; Katritzky, A.R. Efficient Microwave-Assisted Synthesis of Aminoxy Acid Conjugates from Cbz-Protected (α-Aminoxyacyl)benzotriazoles. RSC Advances, 2011, 1, 602–606.
Katritzky, A.R.; Yoshioka-Tarver, M.; Elgendy, B.; Hall, C.D. Synthesis and Photochemistry of pH-Sensitive GFP Chromophore Analogues. Tetrahedron Lett. 2011, 52, 2224-2227.
2010
Katritzky, A.R.; Elgendy, B.; Draghici, B.; Hall, C.D. NMR Study of the Tautomeric Behaviour of N-(α-Aminoalkyl)tetrazoles. J. Org. Chem. 2010, 75(19), 6468-6476.
Ghiviriga, I.; Elgendy, B.; Martinez, H.; Fedoseyenko, D.; Metais, E.P.; Fadli, A.; Katritzky, A.R. Conformational equilibria and barriers to rotation in some novel nitroso derivatives of indolizines and 3- and 5-azaindolizines - an NMR and molecular modeling study. Org. Biomol. Chem. 2010, 8(15), 3518-3527.
Katritzky, A.R.; Hall, C.D.; Elgendy, B.; Draghici, B. Tautomerism in Drug Discovery. J. Comput. Aided Mol. Des. 2010, 24, 475-484.
Katritzky, A.R.; Elgendy, B.; Draghici, B.; Fedoseyenko, D.; Fadli, A.; Metais, E. 1H, 13C, and 15N NMR Spectra of Some Pyridazine Derivatives. Magn. Reson. Chem. 2010, 48(5), 397-402.
2009
Ghiviriga, I.; Elgendy, B.; Steel, P.J.; Katritzky, A.R. Tautomerism of guanidines studied by 15N NMR: 2-hydrazono-3-phenylquinazolin-4(3H)-ones and related compounds. Org. Biomol. Chem. 2009, 7(19), 4110-4119.
Katritzky, A.R.; Tala, S.R.; Abo-Dya, N.E.; Gyanda, K.; Elgendy, Bahaa; Abdel-Samii, Z.K.; Steel, P.J. Selective synthesis and structural elucidation of S-acyl- and N-acylcysteines. J. Org. Chem. 2009, 74(18), 7165-7167.
2008
Katritzky, A.R.; Elgendy, B.; Todadze, E.; Abdel-Fattah, A.A.A. (α -Aminoacyl)amino-substituted heterocycles and related compounds. J. Org. Chem. 2008, 73(14), 5442-5445.
2007
Katritzky, A.R.; Abdel-Fattah, A.A.A.; Idzik, K.R.; Elgendy, B.; Soloducho, J. Benzotriazole-mediated alkoxyalkylation and acyloxyalkylation. Tetrahedron 2007, 63(28), 6477-6484.
